| 세션명 | 대학원생 구두발표 (I) |
|---|---|
| 발표장 | 제10회장 |
| 논문코드 | O10-14 |
| 발표일 | 2024-04-3 |
| 발표시간 | 16:30-16:45 |
| 논문제목 | Development of Amphiphilic Poly-β-Peptide Derivatives with Various Poly(ethylene glycol)s for Efficient mRNA Delivery |
| 발표자 | 임성빈 |
| 발표자 소속 | 인하대학교 |
| 저자 | 임성빈, 김현진† |
| 소속 | 인하대학교 |
| 논문초록 | The mRNA vaccines are currently being researched for applications in various diseases by delivering mRNA into cells. To deliver mRNA into cells, it’s important to protect it from extracellular elements like nucleases. This can be achieved by encapsulating mRNA with polymers to form polymer nanoparticles (PNPs), enabling delivering mRNA into cells. Poly-β-peptide derivatives were synthesized with various degree of polymerization (DP) while maintaining high yields and low polydispersity by using β-amino acid N-thiocarboxyanhydrides (β-NTAs) via open-vessel ring-opening polymerization. Additionally, PGly(DET/CHE) were developed, incorporating diethylenetriamine (DET) for adjusting pKa values to facilitate endosomal escape and 2-cyclohexylethylamine (CHE) for regulating log P values to control colloidal stability. As a result, the physiological and biological properties of PNPs were analyzed based on PEG length and further assessed mRNA expression levels in cells and mice. |
THE POLYMER SOCIETY OF KOREA